Genomics and nucleic acids at the genomic level, state-of-the-art computational methods are being used for a broad range of applications to enhance our understanding of molecular evolution at a cellular level, we are unravelling the molecular basis of nucleic acid stability, dna damage repair and various rna processes. Rna isolation for mirna expression profiling, total rna was isolated using the mirvana mirna isolation kit (ambion) following manufacturer instructions, purified using dnase i (invitrogen) digestion, and recovered by acid phenol:chloroform. “detection of molecular pathways of copper in c neoformans using rna interference” – christina boutros (2008) “effect of copper on total protein composition in cryptococcus. Contents from the director’s desk the past glory distinguished alumni and associates the laurels the key committees executive summary biological chemistry centre for advanced ma.
Rnai (rna interference) or ptgs (post transcriptional gene silencing) mutations including mutants with radiation, chemicals, or insertional mutagenesis phenotypic evaluation and selection of novel plant phenotype. Nanoscience news info mon 26 nov 16:30: title to be confirmed dr tom simmons, founder & ceo of cambridge glycoscience professor paul dupree, scientific advisor, cambridge glycoscience crispr /cas systems in bacteria and rna interference pathways in plants, fungi, and animals. The higgs boson is an elementary particle in the standard model of particle physics, rutherford thomson chadwick bose on 22 june 2012 cern announced an upcoming seminar covering tentative findings for 2012,.
Utilizing in-vitro & in-silico drug discovery approaches including mammalian cell culture (adherent), rna interference, reverse transcription polymerase chain reaction (rt-pcr), qpcr, western blot, luciferase assay, homology modelling, screening of compound libraries, we show, inhibition of the t-rna ligase rtcb/hspc117 that directly joins the. Using this feedback, we realized that optimizing data visualization would be a critical aspect of the report generation the traditional “narrative” style reporting is too cumbersome for the amount of data generated by large cancer gene panels, whole exome and whole genome sequencing. Various types of stress, such as disruption of calcium homeostasis, inhibition of protein glycosylation and reduction of disulfide bonds, result in accumulation of misfolded prote. Click here to download complete bio-data research focus of ddru : a development of a new drug or lead compound is an extremely complex process, with average costs over $900 million and a time span up to 15 years.
On friday, january 31, 2014 dr indrani bose gave a seminar about her area of research, and discussed her research objectives the title of the seminar was “using rna interference to understand the virulence and biology of the yeast cryptococcus neoformans. First published in 1869, nature is the world’s leading multidisciplinary science journal nature publishes the finest peer-reviewed research that drives ground-breaking discovery, and is read by. View dr trinath chowdhury’s profile on linkedin, the world's largest professional community dr trinath has 1 job listed on their profile see the complete profile on linkedin and discover dr trinath’s connections and jobs at similar companies. The research effort in my group is focused on harnessing transformative genomics technology to understand the genetics of plant development, and to discover how the cooperative roles of dna methylation, histone modifications, and rnai function in establishment and maintenance of epigenetic states throughout plant genomes. Rna-interference in rice against rice tungro bacilliform virus results in its decreased accumulation in inoculated rice plants transgenic res 17: 897-904 tyagi, h, s rajasubramaniam and i dasgupta 2007.
The use of rna interference to abrogate expression of each mkp isoforms, may help to provide quick answers to these questions the mechanisms of erk nuclear import and export are still largely unknown. Guwahati established department of biotechnology in the year 2002 the department is one of its dr b bose dr a ramesh dr s patra 5 (2008-2013) novel nanoscale materials targeted for virus resistance using the tool of rna interference (rnai) dbt 8334 dr sunil kumar mukherjee, icgeb, new delhi 3. Following this you can design the 3d structure of your rna using rna composer (500nt) servers so at this point you would have a 3d protein structure and a 3d rna structure.
Delivered invited lecture at the biochemistry and molecular biology (bmb) seminar series, department of biochemistry & molecular biology, mayo clinic, minnesota during march 30, 2010 delivered invited lecture at the csir-central drug research institute, lucknow, on july 19, 2010 on the occasion of the diamond jubilee year of the institute. Genome sequencing (45, 88) and rna interference (69) to our present understanding of the biochemical reactions in structural studies these tools, coupled with the facts that gene capsule synthesis is patchy. The use of the rna interference (rnai) pathway to eliminate gene products has greatly facilitated the understanding of gene function behind this remarkable pathway is an intricate network of proteins that ensures the degradation of the target mrna.